Skip to main content
. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 3;22(4):1441–1449. doi: 10.1016/j.bmc.2013.12.056

Table 3.

Anti-proliferative activities of analogues 87–94, 104, 96, 98.

graphic file with name nihms560377u4.jpg
Entry X R1 R SKBr3 (IC50, μ M) MCF7 (IC50, μ M) PC3 MM2 (IC50, μ M) LN CaP (IC50, μ M) 253JB-V (IC50, μ M)
87 CH H f 2.32±0.61 1.39±0.1 NT NT NT
88 N OH f 1.30±0.08 1.43±0.19 NT NT NT
89 N OCH2CH3 f 1.86±0.27 1.97±0.17 >100 >100 NT
90 N OCH2(CH2)2CH3 f 1.06±0.02 1.72±0.33 2.23±0.02 2.06±0.06 NT
91 N OCH2CH2Ph f 1.89 ±0.4 3.19 ±0.6 2.46±0.37 2.37±0.04 NT
92 N H f 1.14±0.21 1.26±0.09 1.93±0.1 NT NT
93 N O-d d 0.34±0.21 0.49±0.17 1.75±0.13 1.86±0.03 1.39±0.17
94 N O-f f 0.58±0.24 0.57±0.14 1.74±0.14 1.9±0.07 NT
96 N O-h f 0.64±0.31 0.67±0.42 1.75±0.1 1.79±0.2 1.30±0.15
98 N O-d f 0.59±0.05 1.58±0.16 2.4±0.12 2.6±1.10 NT