Figure 2. Fat metabolism.

(A) Plasma palmitate concentration, (B) plasma free fatty acid (FFA) concentration, (C) palmitate oxidation, and (D) total fatty acid oxidation (FAO) at rest (gray) and during exercise at 50% to 60% of maximal oxygen uptake capacity (V̇o₂max) (black) without and with bezafibrate (green) in 10 patients with carnitine palmitoyltransferase II (n = 5) and very long-chain acyl-CoA dehydrogenase (n = 5) deficiencies. Values are mean ± standard error (SE). *p < 0.05 rest vs exercise; ^§p < 0.05 placebo vs bezafibrate. Dotted line indicates the mean fatty acid/palmitate oxidation at the 40th minute of exercise in 7 healthy controls exercising at 50% to 60% of V̇o₂max, and the shaded area is ±SE.