Table 3.
The main simulation results using the hybrid algorithm with sample size 72 and cohort 3. The true time distribution is assumed to be lognormal.
| Scenario | 1-Day Schedule
|
2-Day Schedule
|
None |
Rselect Rtreat |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Dose 1 | Dose 2 | Dose 3 | Dose 1 | Dose 2 | Dose 3 | ||||
| 1 | ūtrue(s, d) | 52.2 | 57.5 | 62.9 | 52.2 | 57.5 | 62.9 | ||
| % Sel | 5 | 8 | 38 | 5 | 8 | 35 | 1 | 0.82 | |
| # Pats | 11.6 | 9.8 | 14.5 | 11.6 | 9.5 | 14.4 | 0.54 | ||
|
| |||||||||
| 2 | ūtrue(s, d) | 59.0 | 53.7 | 48.1 | 59.0 | 53.7 | 48.1 | ||
| % Sel | 39 | 7 | 4 | 39 | 6 | 5 | 1 | 0.85 | |
| # Pats | 22.6 | 8.2 | 5.0 | 22.7 | 8.2 | 4.9 | 0.75 | ||
|
| |||||||||
| 3 | ūtrue(s, d) | 53.1 | 58.4 | 63.8 | 56.8 | 62.1 | 67.6 | ||
| % Sel | 3 | 5 | 16 | 6 | 12 | 58 | 1 | 0.81 | |
| # Pats | 11.1 | 9.1 | 12.9 | 11.6 | 10.5 | 16.5 | 0.54 | ||
|
| |||||||||
| 4 | ūtrue(s, d) | 58.6 | 54.6 | 49.7 | 55.4 | 51.4 | 46.5 | ||
| % Sel | 54 | 12 | 5 | 18 | 5 | 5 | 1 | 0.80 | |
| # Pats | 23.1 | 9.0 | 5.1 | 21.0 | 8.3 | 5.1 | 0.69 | ||
|
| |||||||||
| 5 | ūtrue(s, d) | 52.9 | 63.6 | 50.2 | 52.9 | 63.6 | 50.2 | ||
| % Sel | 8 | 34 | 6 | 9 | 36 | 6 | 1 | 0.74 | |
| # Pats | 13.0 | 16.7 | 0.5 | 12.8 | 16.7 | 6.2 | 0.54 | ||
|
| |||||||||
| 6 | ūtrue(s, d) | 53.5 | 48.1 | 56.5 | 53.5 | 48.1 | 56.5 | ||
| % Sel | 21 | 4 | 23 | 21 | 4 | 25 | 2 | 0.76 | |
| # Pats | 17.2 | 7.3 | 11.0 | 17.2 | 7.2 | 11.2 | 0.62 | ||
|
| |||||||||
| 7 | ūtrue(s, d) | 35.3 | 34.2 | 33.0 | 35.3 | 34.2 | 33.0 | ||
| % Sel | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 0.87 | |
| # Pats | 5.0 | 1.6 | 0.5 | 5.0 | 1.6 | 0.5 | 0.81 | ||
|
| |||||||||
| 8 | ūtrue(s, d) | 39.9 | 37.8 | 35.6 | 39.9 | 37.8 | 35.6 | ||
| % Sel | 1 | 0 | 1 | 1 | 0 | 1 | 96 | 0.54 | |
| # Pats | 5.8 | 4.0 | 4.5 | 5.8 | 4.0 | 4.5 | 0.54 | ||