Table III.
Regression coefficients for the association of low-density lipoprotein cholesterol (mmol/L) with systolic blood pressure (mmHg) adjusting for body mass index (kg/m2) from complete-data, complete-case, and multiple imputation analyses with stratified and within-study imputation models using stratified, fixed-effects, and random-effects meta-analysis models: estimates with standard error (in brackets). In inverse-variance weighted analyses, it is indicated whether Rubin's rules were applied within each study prior to meta-analysis (RR then MA) or meta-analysis of imputed datasets was performed prior to combining estimates using Rubin's rules (MA then RR).
| Analysis model: | Stratified | Fixed-effect | Random-effects | |
|---|---|---|---|---|
| Complete-data | 1.219 (0.078) | 1.084 (0.069) | 1.189 (0.225) | |
| Complete-case | 1.230 (0.088) | 1.105 (0.078) | 1.166 (0.231) | |
| Stratified imputation | (MA then RR) | 1.248 (0.093) | 1.093 (0.081) | 1.278 (0.220) |
| (RR then MA) | 1.099 (0.077) | 1.278 (0.211) | ||
| Within-study imputation | (MA then RR) | 1.236 (0.089) | 1.112 (0.079) | 1.165 (0.239) |
| (RR then MA) | 1.110 (0.078) | 1.177 (0.226) | ||