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. Author manuscript; available in PMC: 2014 Mar 24.
Published in final edited form as: Genes Brain Behav. 2010 Oct 19;10(2):166–175. doi: 10.1111/j.1601-183X.2010.00652.x

Figure 3. Fear conditioning by serotonin transporter genotype.

Figure 3

Mean (and standard error) percent freezing data of wild-type (WT) and serotonin transporter knockout (KO) mice are shown for 3 conditions. Freezing is defined as the absence of all but breathing related movement. In the "Baseline" condition, percent freezing is shown for the period in the first day of conditioning, before any tones or shocks were presented. For the "Context" condition, freezing is shown for the period in the second day before any tones or shocks were presented. For the "Tone" condition, the difference in freezing percent is shown between the period following the first tone onset on the third day (on which the context was altered, and no shocks were presented) and the freezing percent observed in the period just prior to that tone onset. There was no significant difference between genotypes in the baseline condition. KO mice froze less than WT animals to the context, but did not differ significantly in freezing to the tone. Animals exposed to paired tone-shock presentations on days 1 and 2 froze more to the tone (alone) on day 3 than animals exposed to unpaired tones and shocks on days 1 and 2. * p < .05, ** p < .01.