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. 2013 Mar 16;73(4):691–696. doi: 10.1136/annrheumdis-2012-202709

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Erosive progression over time in all 2681 evaluable rheumatoid arthritis (RA) patients. Progression trajectories were adjusted for differences in patient characteristics at their first x-ray (table 1), (A,C) DAS including the 28-joint count for tender and swollen joints and erythrocyte sedimentation rate (DAS28_ESR) or (B,D) clinical disease activity index where indicated, plus anti-inflammatory therapies and covariates of RA severity. Values are mean and 95% CI. Erosion scores progressed significantly faster in patients with anaemia than in non-anaemic RA patients. The kinetics of damage progression accelerated with the grade of anaemia severity. (A and C) For comparison, the lower margin of the shaded area represents mean damage progression in clinical remission (DAS28_ESR<2.6), and the upper margin disease progression in patients with high clinical disease activity (DAS28_ESR>5.1). Patient numbers at given time points are the same in left (A,C) and right hand figures (B,D).