Table II. Age-adjusted Clinical Characteristics of Peripheral Arterial Disease Participants Across WIQ Score Quartiles (n=638).
| WIQ Stair Climbing Score Quartiles | |||||
|---|---|---|---|---|---|
| 1st Quartile [≤ 25.0] |
2nd Quartile [25.0 – 41.7] |
3rd Quartile [41.7 – 66.7] |
4th Quartile [> 66.7] |
p for trend |
|
| Male, % | 40.3* | 52.2* | 63.2 | 73.9* | < 0.001 |
| Black race, % | 23.3 | 11.3 | 13.9 | 16.4 | 0.06 |
| ABI | 0.64 (0.01) | 0.63 (0.01) | 0.66 (0.01) | 0.66 (0.01) | 0.10 |
| BMI, kg/m2 | 29.0* (0.4) | 27.2 (0.4) | 27.5 (0.4) | 26.6 (0.4) | < 0.001 |
| Current Smoker, % | 15.6 | 18.8 | 16.1 | 19.0 | 0.37 |
| Angina, % | 36.0* | 41.8 | 30.8 | 25.8 | 0.01 |
| CHF, % | 32.7* | 29.2 | 13.7 | 15.6* | < 0.001 |
| MI, % | 31.0* | 28.4 | 23.4 | 14.9* | 0.002 |
| Pulmonary Disease, % | 49.9* | 37.1 | 31.6 | 22.2* | < 0.001 |
| Cancer, % | 12.0 | 20.1 | 21.1 | 16.7 | 0.31 |
| Diabetes,% | 40.0 | 26.2 | 25.3 | 31.1 | 0.05 |
| Blocks walked in the past week, n |
14.3* (4.1) | 26.5* (4.6) | 43.4 (4.1) | 48.9 (4.6) | < 0.001 |
| Pain on exertion and rest | 35.1 | 22.1 | 11.3 | 7.68 | < 0.0001 |
| Atypical exertional leg pain/stop |
18.0 | 14.9 | 30.3 | 21.5 | 0.088 |
| Atypical exertional leg pain/carry on |
1.67 | 9.86 | 7.45 | 20.2 | < 0.0001 |
| Asymptomatic PAD | 19.2 | 12.7 | 20.4 | 28.4 | 0.015 |
| Intermittent claudication | 25.5 | 40.0 | 29.8 | 22.1 | 0.263 |
| Six minute walk, ft | 846.6 (24.5) | 1091.4 (27.0) | 1271.2 (24.1) | 1311.6 (27.1) | <.0001 |
| Four meter velocity at usual speed, m/sec |
0.74 (0.01) | 0.87 (0.02) | 0.94 (0.01) | 0.96 (0.02) | <.0001 |
| Four meter velocity at fast speed, m/sec |
1.00 (0.02) | 1.17 (0.02) | 1.27 (0.02) | 1.31 (0.02) | <.0001 |
| Statin use,% | 40.2 | 44.2 | 46.6 | 41.6 | 0.63 |
| Inhibitor use, % | 29.4 | 27.1 | 27.3 | 27.6 | 0.73 |
| WIQ Distance Score Quartiles | |||||
|---|---|---|---|---|---|
| 1st Quartile [≤ 14.5] |
2nd Quartile [14.5 – 37.1] |
3rd Quartile [37.1 – 67.9] |
4th Quartile [> 67.9] |
p for trend |
|
| Male, % | 49.0* | 53.5* | 56.6 | 67.9* | < 0.001 |
| Black race, % | 24.1 | 20.2 | 9.0 | 12.6* | 0.001 |
| ABI | 0.59* (0.01) | 0.64* (0.01) | 0.66* (0.01) | 0.70 (0.01) | < 0.001 |
| BMI, kg/m2 | 28.9* (0.4) | 27.8 (0.4) | 27.2 (0.4) | 26.7 (0.4) | < 0.001 |
| Current Smoker, % | 14.0 | 19.8 | 18.2 | 16.8 | 0.90 |
| Angina, % | 40.5 | 32.8* | 35.5 | 25.0* | 0.01 |
| CHF, % | 31.0 | 22.0 | 17.4 | 19.2* | 0.002 |
| MI, % | 31.6* | 27.7 | 20.6 | 17.3* | 0.001 |
| Pulmonary Disease, % | 46.4 | 32.8 | 35.7 | 28.6* | 0.001 |
| Cancer, % | 16.7 | 19.7 | 17.0 | 16.6 | 0.92 |
| Diabetes,% | 40.0 | 26.5 | 26.1 | 31.7 | 0.18 |
| Blocks walked in the past week, n |
10.9* (4.2) | 23.9* (4.1) | 31.4* (4.2) | 64.4 (4.2) | < 0.001 |
| Pain on exertion and rest | 32.4 | 19.9 | 18.1 | 7.65 | < 0.0001 |
| Atypical exertional leg pain/stop |
17.1 | 22.0 | 27.1 | 20.5 | 0.48 |
| Atypical exertional leg pain/carry on |
1.27 | 5.65 | 7.75 | 21.8 | < 0.0001 |
| Asymptomatic PAD | 11.3 | 15.1 | 15.7 | 38.5 | < 0.0001 |
| Intermittent claudication | 37.5 | 36.4 | 30.4 | 11.3 | < 0.0001 |
| Six minute walk, ft | 783.8 (24.6) | 1107.1 (24.0) | 1230.8 (24.2) | 1375.9 (24.2) | < 0.0001 |
| Four meter velocity at usual speed, m/sec |
0.76 (0.02) | 0.87 (0.02) | 0.91 (0.02) | 0.96 (0.02) | < 0.0001 |
| Four meter velocity at fast speed, m/sec |
1.03 (0.02) | 1.18 (0.02) | 1.24 (0.02) | 1.29 (0.02) | <.0.0001 |
| Statin use,% | 43.2 | 39.8 | 46.0 | 42.8 | 0.99 |
| Inhibitor use, % | 29.2 | 24.9 | 28.5 | 28.1 | 0.75 |
| WIQ Speed Score Quartiles | |||||
|---|---|---|---|---|---|
| 1st Quartile [≤ 17.4] |
2nd Quartile [17.4 – 32.6] |
3rd Quartile [32.6 – 54.3] |
4th Quartile [> 54.3] |
p for trend |
|
| Male, % | 47.5* | 50.4* | 58.2 | 71.4* | < 0.001 |
| Black race, % | 24.0 | 16.8 | 12.0 | 14.0* | 0.04 |
| ABI | 0.62* (0.01) | 0.62* (0.01) | 0.67 (0.01) | 0.68 (0.01) | < 0.001 |
| BMI, kg/m2 | 29.4* (0.4) | 27.6* (0.4) | 27.1 (0.4) | 26.5 (0.4) | < 0.001 |
| Current Smoker, % | 12.4 | 19.1 | 18.3 | 19.0 | 0.62 |
| Angina, % | 40.0 | 30.8* | 38.0 | 25.4* | 0.02 |
| CHF, % | 31.4* | 28.3* | 20.0 | 11.2* | < 0.001 |
| MI, % | 32.6 | 23.3 | 24.1 | 18.0* | 0.01 |
| Pulmonary Disease, % | 41.0* | 40.2 | 33.2 | 27.2* | < 0.001 |
| Cancer, % | 11.4 | 20.5 | 20.1 | 17.0 | 0.05 |
| Diabetes,% | 37.5 | 35.8 | 27.4 | 23.9 | 0.01 |
| Blocks walked in the past week, n |
11.5* (4.2) | 22.6* (4.2) | 37.3* (4.1) | 59.8 (4.3) | < 0.001 |
| Pain on exertion and rest | 32.7 | 23.9 | 15.7 | 6.50 | < 0.0001 |
| Atypical exertional leg pain/stop |
16.9 | 22.6 | 22.9 | 21.9 | 0.4924 |
| Atypical exertional leg pain/carry on |
3.10 | 3.77 | 11.4 | 18.2 | < 0.0001 |
| Asymptomatic PAD | 16.3 | 15.7 | 18.5 | 31.0 | 0.001 |
| Intermittent claudication | 30.3 | 33.2 | 30.8 | 22.4 | 0.035 |
| Six minute walk, ft | 815.0 (24.2) | 1037.2 (23.7) | 1248.0 (23.2 | 1397.5 (24.6) | <.0001 |
| Four meter velocity at usual speed, m/sec |
0.74 (0.01) | 0.84 (0.01) | 0.92 (0.01) | 0.99 (0.01) | <.0001 |
| Four meter velocity at fast speed, m/sec |
1.00 (0.02) | 1.13 (0.02) | 1.27 (0.02) | 1.34 (0.02) | <.0001 |
| Statin use,% | 43.5 | 42.7 | 47.2 | 39.2 | 0.78 |
| Inhibitor use, % | 27.7 | 36.5 | 28.4 | 20.4 | 0.08 |
Values shown are mean (Standard Error) unless otherwise indicated. WIQ = Walking Impairment Questionnaire; PAD = peripheral arterial disease; ABI = ankle brachial index; BMI = body mass index; CHF = congestive heart failure; MI = myocardial infarction.
*
for pairwise comparison with 4th quartile (best) as referent, p value < 0.05