Table 2.

Likelihood of persistent CRA by personal characteristics among premenopausal women diagnosed with breast cancer (N=431).

Variable	Unadjusted			Multivariable^a

	OR	95% CI	p-value	OR	95% CI	p-value
Reproductive History
Nulliparity
No	1.00	Referent		1.00	Referent
Yes	0.72	0.46-1.13	0.15	1.34	0.69-2.62	0.39
Nulligravidity
No		Referent		1.00	Referent
Yes	0.78	0.47-1.27	0.32	1.15	0.55-2.43	0.71
Age at Menarche
<12	1.02	0.60-1.76	0.95	0.80	0.36-1.78	0.58
12-13	1.00	Referent		1.00	Referent
>13	1.31	0.81-2.13	0.27	2.22	1.06-4.64	0.03
	p-value, test for trend = 0.76			p-value, test for trend = 0.03
Age at first birth
<25	1.00	Referent		1.00	Referent
25-29	1.36	0.73-2.55	0.34	1.60	0.60-4.21	0.35
30-34	0.57	0.33-0.99	0.04	0.67	0.30-1.50	0.32
≥35	1.29	0.56-2.99	0.55	1.13	0.33-3.84	0.84
	p-value, test for trend = 0.80			p-value, test for trend = 0.60
Lifestyle Factors
Alcohol (drinks per week)
<1	1.00	Referent		1.00	Referent
1-4	1.15	0.72-1.84	0.55	0.99	0.49-1.97	0.97
5-9	1.30	0.62-2.71	0.49	0.83	0.28-2.46	0.73
10-19	3.33	0.90-12.3	0.07	2.04	0.31-13.3	0.46
	p-value, test for trend = 0.08			p-value, test for trend = 0.74
Cigarette Smoking
Never	1.00	Referent		1.00	Referent
Past	1.04	0.70-1.56	0.84	1.33	0.72-2.45	0.37
Current	1.42	0.70-2.89	0.33	2.41	0.86-6.75	0.09
Anthropometry
Weight (kg)	1.01	1.00-1.02	0.22	1.01	0.98-1.03	0.66
Height (inches)	1.00	0.97-1.03	0.92	1.02	0.98-1.07	0.32
BMI (kg/m²)	1.03	0.99-1.07	0.22	1.00	0.94-1.06	0.99
Underweight^b	0.91	0.48-1.73	0.77	1.19	0.45-3.11	0.73
Healthy	1.00	Referent		1.00	Referent
Overweight/obese^b	1.69	1.09-2.64	0.02	1.52	0.79-2.93	0.21

OR = odds ratio, CI = confidence interval,

Multivariable model adjusted for patient age at diagnosis, type and regimen of chemotherapy including AC, T, H, DD and Tam, follow-up time, weight, gravidity, parity, age at menarche, smoking status, and alcohol consumption.

underweight = BMI<20.0 kg/m²; overweight/obese = BMI >24.9 kg/m²