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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: ACS Nano. 2013 Nov 11;7(12):10671–10680. doi: 10.1021/nn403370e

Figure 4. Comparison of biodistribution and tumor accumulation of targeted and non -targeted NPs with similar biophysicochemical properties.

Figure 4

(A & B) Fluorescence intensity of Alexa-488 labeled targeted NPs associated with LNCaP cells (A) and macrophages (B) normalized by that of non-targeted NPs. Blue and red bars indicate non-targeted and targeted NP formulations, respectively, selected for in vivo studies. (C) Biodistribution and (D) tumor accumulation of a targeted NP composed of 14 mol% PLGA-PEG-LIG and non-targeted NP. **Statistically significant by t-test with p < 0.005. Error bars denote ±S.D.