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Clockwise from left: The Greek island of Naxos. A nuclear Naxos disease family. Analysis reveals the presence of a mutant allele (one bold band) in the homozygous boy and the wild-type (two light bands) coexisting with the mutant allele in the heterozygous carrier parents. Classic symptoms of Naxos disease, keratoderma striate in palmar and diffuse in plantar areas in the homozygous boy and wooly hair [41].
