Table 1 .
Milestones of early heart development shared by different organisms. (modified from 57 ).
| Cardiac Events | Human | Mouse | Zebrafish |
| Migration of precardiac cells from epiblast | 15–16 days | 7 dpc (primitive streak) | 50% epiboly (5.5 hpf) |
| First evident assembly of myocardial plate | 18 days | 7 dpc (late primitive streak) | 8–10 somites (∼13 hpf) |
| Generation of single heart tube initiated | 22 days (4–10 somites) | 8 dpc (5–10 somites) | 20 somites (∼19 hpf) |
| Tubular heart starts contraction | 23 days | 8.5 dpc (8–10 somites) | 26 somites (22 hpf) |
| Looping | 23 days | 8.5 dpc | 33 hpf |
| Endocardial cushions form | 28 days (30–38 somites) | 9.5 dpc | 48 hpf |