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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Cancer Res. 2014 Jan 21;74(5):1338–1348. doi: 10.1158/0008-5472.CAN-13-2357-T

Table 1.

Brief summary of the major findings.

Samples Results
Distant metastases Genetic diversity overall is high especially in TNBCs
Genetic diversity indices are similar regardless of the probe used
Two lesions in the same patients have significantly different diversity in some cases and some probes
In some cases genetic diversity differs between the two metastatic lesions only in some cell types
Two lesions in the same patient are frequently phenotypically distinct except in TNBC cases
Matched primary tumors and lymph node metastases Genetic diversity overall is lower than in distant metastases, especially true in TNBCs
Genetic diversity indices are similar regardless of the probe used
Genetic diversity is significantly different in most cases and most probes
Diversity for 8q24 is lower in some primary TNBCs and higher in the lymph node metastasis
Diversity for 8q24 is higher in some primary Her2+ tumors and lower in the lymph node metastasis
Primary and matched lymph node metastasis are phenotypically more similar in most cases