Table 1.

Clinicopathologic features of consecutive 42 patients with diagnosis of anal cancer

Clinical features	Male (N =23)		Female (N =19)		Overall (N =42)		P value
Age (mean±SD)	58±15		61±11		59±13
Age of HIV-positive patients (mean±SD)	44±7		47±9		44±7		<0.0001a
Age of HIV-negative patients (mean±SD)	69±10		62±10		65±10
	N	%	N	%	N	%
HIV+	10	43 %	2	11 %	12	29 %	0.04b
HIV−	13	57 %	17	89 %	30	71 %
Stage
I	2	9 %	5	26 %	7	17 %	0.55c
II	11	48 %	5	26 %	16	38 %
III	7	30 %	6	32 %	13	31 %
IV	1	4 %	3	16 %	4	10 %
Unknown	2	9 %	0	0 %	2	4 %
Outcome
Tumor recurrence +	9	39 %	4	21 %	13	31 %	0.21d
Tumor recurrence −	14	61 %	15	79 %	29	69 %
Histopathologic features
HPV positivity	23	100 %	19	100 %	42	100 %
p16 positivity	23	100 %	19	100 %	42	100 %
Histologic tumor type
Non-keratinizing	12	52 %	15	79 %	27	64 %	0.07e
Keratinizing	11	48 %	4	21 %	15	36 %

^aT test for difference in age between HIV-positive vs. HIV-negative patients

^bFisher’s exact test for difference in HIV positivity between men and women

^cPearson’s chi-square test for difference in local tumors (stage I/II) and advanced tumors (stage III/IV) between men and women

^dPearson’s chi-square test for difference in rate of recurrence between men and women

^ePearson’s chi-square test for the difference in tumor histologic type distribution between men and women