Extended Data Figure 3. Structure-based sequence alignment of SUVH family proteins from Arabidopsis.

The secondary structural elements of SUVH9 are labeled on the top of the sequence alignment. The domain boundaries are marked on the top and depicted with color-coding as in Figure 1a. Conserved residues involved in the interaction with flipped 5mC base and the DNA backbone available from the published SUVH5-DNA complex structures are highlighted with cyan circles and blue hexagons, respectively. The insertions in the SET domains are highlighted with a purple box. The zinc-coordinating Cys residues are highlighted with black stars in the SET domain and grey stars in the post-SET domain. Two-tyrosine residues that are conserved and normally important for enzymatic activity are highlighted with red dots.