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. Author manuscript; available in PMC: 2014 Mar 24.
Published in final edited form as: Cell. 2013 Jan 31;152(3):599–611. doi: 10.1016/j.cell.2012.12.028

Figure 7. Tumor Suppressor Role of PKCζ in Human Colon Cancer.

Figure 7

(A) Gene expression analysis of PKCζ in human colon cancer samples in public microarray data.

(B) Kaplan-Meier curves comparing the survival of patients with high versus low expression of PKCζ.

(C) Representative sections of PKCζ, caspase-3, and PHGDH immunostaining. Scale bars, 50 μm.

(D) Associated correlation of caspase-3 and PKCζ expression in human colon cancer TMA. Nuclear PKCζ expression positively correlates with active caspase-3 levels. **p < 0.01.

(E) Associated correlation of PHGDH and PKCζ expression in human colon cancer TMA. Nuclear PKCζ expression negatively correlates with PHGDH levels. *p < 0.05.

(F) Negative correlation between PKCζ and PSAT1 mRNA levels in human colorectal carcinomas.