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. 2014 Mar 24;9(3):e85345. doi: 10.1371/journal.pone.0085345

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) siRNA induced knock-down of AP-1 in-vivo prevented the IL-6 induced increase in mouse intestinal claudin-2 protein expression as assessed by Western blot analysis. B) AP-1 siRNA transfection in-vivo prevented the IL-6 induced drop in mouse intestinal TER as measured in Ussing chambers (n = 5). _*, p<0.001 vs. control; _**, p<001 vs. IL-6 treatment.