Table 4. Effects of ezetimibe, simvastatin or the combination treatment on the number of subjects with an increase or decrease in HDL subfractions.
| HDL subclass | Change | Treatment | P-value | ||
| Ezetimibe | Simvastatin | Ezetimibe+simvastatin | |||
| Large HDL | Increase | 9 | 18 | 19 | |
| Decrease | 13 | 6 | 5 | P = 0.01 | |
| Intermediate HDL | Increase | 13 | 12 | 11 | |
| Decrease | 9 | 12 | 13 | ||
| P = 0.66 | |||||
| Small HDL | Increase | 13 | 6 | 9 | |
| Decrease | 9 | 18 | 15 | P = 0.06 | |
The data indicate the number of subjects in the respective group. P-values were calculated using Pearson chi-square tests.