Figure 1. Subtype-specific drug resistance mutation sites analysis.

Note: horizontal numbers indicate drug resistance mutation sites in RT region with significant difference among subtypes, vertical percentage indicate the proportion of mutated amino acids differ from the subtype B consensus sequence. Black columns means only amino acids distribution with significant difference among subtypes (chi-square or fisher's exact test, p<0.05), white columns means both mutated amino acids distribution and genetic barriers with significant difference among subtypes (Kruskal Wallis test, p<0.05).