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. 2014 Mar 24;9(3):e92373. doi: 10.1371/journal.pone.0092373

Figure 6. Evaluation of possible exogenous rmTNF toxicity in bone marrow and spleen.

Figure 6

Representative images of H&E stained bone marrow and spleen tissue. (A–B) Bone marrow - There was granulocytic hyperplasia in the BM of mice with necrotic tumors in rmTNF-injected groups, reflected by a shift of the myeloid/erythroid ratio (∼3:1 vs. ∼8:1) in the BM (erythroid islands indicated within the encircled areas). (C–F) Spleen - There was a marked increase in extramedullary hematopoiesis in spleens of mice with necrotic tumors in rmTNF injected indicated by the cellularity within the encircled regions between normal lymphoid tissue (white pulp).