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. 2014 Mar 24;9(3):e92498. doi: 10.1371/journal.pone.0092498

Table 2. Genes significantly upregulated by cigarette smoke exposure in the human and mouse lungs.

HUMANS MICE
Gene name GeneAbbreviation FoldIncrease Human p-value FoldIncrease Mice p-value
Acid phosphatase 5, tartrate resistant ACP5 2.2 1.46E-015 2.5 6.83E-004
Aryl hydrocarbon receptor repressor AHRR 6.1 3.28E-020 11.8 1.43E-004
Aldehyde dehydrogenase 3 family, member A1 ALDH3A1 4.0 7.11E-015 11.2 1.05E-003
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 ATP6V0D2 5.9 7.64E-016 4.5 2.87E-003
Basic helix-loop-helix family, member e41 BHLHE41 2.1 1.02E-015 3.5 5.92E-004
C-type lectin domain family 5 member A CLEC5A 3.3 9.15E-018 5.8 8.34E-003
Cytochrome P450 1B1 CYP1B1 4.5 1.14E-019 12.5 6.78E-003
Growth differentiation factor 15 GDF15 2.8 1.83E-014 2.3 1.06E-004
Glutathione S-Transferase Alpha 2 GSTA2 3.6 3.74E-006 2.18 2.78E-003
Lipocalin-2 LCN2 2.2 1.56E-008 6.1 2.77E-002
Matrix metalloproteinase-12 MMP12 4.0 1.89E-013 26.3 4.63E-003
NIMA (never in mitosis gene a)-related kinase 6 NEK6 2.0 1.27E-016 2.1 2.38E-003
NAD(P)H dehydrogenase, quinone 1 NQO1 2.0 3.24E-016 5.1 2.89E-006
Phospholipase A2, group VII PLA2G7 3.4 3.82E-012 2.2 1.04E-002
Secreted phosphoprotein 1, Osteopontin SPP1 3.3 5.99E-009 8.3 2.03E-007
Transmembrane 7 superfamily member 4 TM7SF4 4.1 6.27E-016 5.8 3.75E-002
Triggering receptor expressed on myeloid cells 2 TREM2 3.3 4.39E-016 8.6 2.00E-007