Table 3. Common canonical pathways altered by cigarette smoke exposure in the human and mouse lungs.

Ingenuity Canonical Pathways	Species	p-value	Ratio	Genes
Xenobiotic response/detoxification
Aryl Hydrocarbon Receptor Signaling	HUMANS	7.41E-006	5.67E-002	AHRR, GSTA2, ALDH3B2, CYP1A1, CYP1A2, NQO1, ALDH3A1, CYP1B1
	MICE	3.31E-003	5.76E-002	AHRR, CTSD, CCNA2, POLA1, GSTA5, NQO1, ALDH3A1, CYP1B1
Metabolism of Xenobiotics by Cytochrome P450	HUMANS	5.01E-005	6.90E-002	GSTA2, ALDH3B2, CYP1A1, CYP1A2, ALDH3A1, CYP1B1
	MICE	7.41E-003	6.45E-002	ADH7, UGT1A6, GSTA5, HPGDS, ALDH3A1, CYP1B1
Xenobiotic Metabolism Signaling	HUMANS	1.32E-004	3.45E-002	AHRR, LIPA, GSTA2, ALDH3B2, CYP1A1, CYP1A2, NQO1, ALDH3A1, CYP1B1
	MICE	3.39E-003	4.56E-002	PNPLA7, AHRR, UGT1A6, Ces1g, GSTA5, Sult1c2, NQO1, PIK3R5, GCLC, ALDH3A1, CYP1B1, CAMK2B
Phospholipid metabolism/degradation
Glycerophospholipid Metabolism	HUMANS	2.40E-003	4.07E-002	GPD1, PNPLA3, BCHE, PLA2G2A, PLA2G7
	MICE	8.13E-003	5.65E-002	PLCB2 (includes EG:18796), LPCAT2, PLD3, GNA15, ASPG, PLA1A, PLA2G7
Eicosanoid Signaling	HUMANS	9.55E-003	5.17E-002	PNPLA3, PLA2G2A, PLA2G7
	MICE	2.09E-002	7.02E-002	PTGIR, HPGDS, GGT1, PLA2G7
Phospholipid Degradation	HUMANS	2.57E-002	3.57E-002	PNPLA3, PLA2G2A, PLA2G7
	MICE	4.37E-003	7.23E-002	PLCB2 (includes EG:18796), PLD3, GNA15, ASPG, PLA1A, PLA2G7
Glycerolipid Metabolism	HUMANS	3.16E-002	3.30E-002	LIPA, PNPLA3, ALDH3A1
	MICE	7.08E-003	6.52E-002	AKR1B15, GLA, ADH7, LIPF, ALDH3A1, AOAH
Oxidative stress generation/defense
NRF2-mediated Oxidative Stress Response	HUMANS	4.57E-002	2.14E-002	GSTA2, NQO1, GPX2, DNAJC5B
	MICE	3.98E-002	3.89E-002	GSTA5, NQO1, PIK3R5, GCLC, GCLM, MAFF, TXNRD1
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	HUMANS	4.68E-002	2.16E-002	APOE, CYBB, SERPINA1, APOC2
	MICE	1.51E-002	4.52E-002	TLR2, NCF1, CYBA, NCF2, PIK3R5, NCF4, SPI1 (includes EG:20375), SIRPA
Others
Dendritic Cell Maturation	HUMANS	2.75E-002	2.34E-002	CD1A, CD1B, IL37, TREM2
	MICE	1.05E-003	6.00E-002	TLR2, FCGR2A, IL1RN, PIK3R5, FCER1G, CD86, LY75, FCGR2B, TREM2
Hematopoiesis from Pluripotent Stem Cells	HUMANS	4.47E-003	5.45E-002	IL8, LIF, CSF3
	MICE	4.17E-002	6.25E-002	KITLG, FCER1G, IGHA1