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. 2014 Mar 24;9(3):e92498. doi: 10.1371/journal.pone.0092498

Table 4. Common biological functions altered by cigarette smoke exposure in the human and mouse lungs.

Ingenuity BiologicalFunction Species p-value Ingenuity BiologicalFunction Species p-value
Immune system
Inflammatory Response Human 1.19E-10-2.26E-02 Cell-To-Cell Signaling and Interaction Human 1.15E-04-2.26E-02
Mouse 1.35E-16-1.6E-02 Mouse 8.83E-11-1.67E-02
Antigen Presentation Human 1.95E-07-2.26E-02 Hypersensitivity Response Human 3.65E-03-2.26E-02
Mouse 2.09E-08-1.45E-02 Mouse 8.89E-06-1.39E-02
Cellular Movement Human 1.95E-07-2.26E-02 Lymphoid Tissue Structure and Development Human 8.04E-03-8.04E-03
Mouse 4.8E-13-1.62E-02 Mouse 3.74E-07-1.44E-02
Hematological System Development and Function Human 1.95E-07-2.26E-02 Antimicrobial Response Human 5.63E-03-5.63E-03
Mouse 4.8E-13-1.62E-02 Mouse 7.24E-04-7.24E-04
Immune Cell Trafficking Human 1.95E-07-2.26E-02 Hematopoiesis Human 8.36E-04-2.26E-02
Mouse 4.8E-13-1.62E-02 Mouse 3.74E-07-1.44E-02
Cell-mediated Immune Response Human 3.31E-05-2.26E-02 Inflammatory Disease Human 2.47E-04-2.26E-02
Mouse 2.01E-05-1.44E-02 Mouse 2.55E-10-1.31E-02
Metabolism and cellular maintenance
Lipid Metabolism Human 4.18E-06-2.26E-02 Cell Signaling Human 2.71E-04-2.71E-04
Mouse 3.3E-05-1.39E-02 Mouse 1.82E-03-1.25E-02
Energy Production Human 1.45E-05-1.51E-02 Cellular Function and Maintenance Human 2.71E-04-2.26E-02
Mouse 3.28E-03-3.28E-03 Mouse 5.33E-11-1.44E-02
Vitamin and Mineral Metabolism Human 1.45E-05-2.26E-02 Molecular Transport Human 2.71E-04-2.02E-02
Mouse 1.82E-03-5.21E-03 Mouse 2.77E-04-1.39E-02
Nucleic Acid Metabolism Human 2.3E-05-7.58E-03 Gene Expression Human 1.51E-02-1.51E-02
Mouse 1.99E-03-1.99E-03 Mouse 1.19E-02-1.19E-02
Drug Metabolism Human 4.22E-07-2.26E-02 Cell Morphology Human 4.76E-03-1.51E-02
Mouse 5.6E-07-2.77E-04 Mouse 9.66E-04-1.26E-02
Carbohydrate Metabolism Human 5.6E-04-2.26E-02 Cellular Assembly and Organization Human 3.57E-03-1.51E-02
Mouse 4.85E-03-1.18E-02 Mouse 4.36E-04-1.39E-02
Small Molecule Biochemistry Human 4.22E-07-2.26E-02
Mouse 3.3E-05-1.39E-02
Diseases
Cancer Human 2.44E-05-2.26E-02 Hepatic System Disease Human 1.63E-03-2.26E-02
Mouse 1.41E-06-1.56E-02 Mouse 3.28E-03-1.54E-02
Respiratory Disease Human 2.44E-05-2.15E-02 Ophthalmic Disease Human 4.18E-03-2.26E-02
Mouse 2.72E-04-1.64E-02 Mouse 1.01E-03-1.01E-03
Cardiovascular Disease Human 2.66E-04-1.27E-02 Tumor Morphology Human 7.13E-03-2.26E-02
Mouse 4.67E-05-1.61E-04 Mouse 1.01E-03-5.63E-03
Metabolic Disease Human 2.66E-04-2.26E-02 Endocrine System Disorders Human 8.99E-03-1.44E-02
Mouse 1.25E-02-1.25E-02 Mouse 8.49E-05-1.25E-02
Connective Tissue Disorders Human 3.86E-04-2.26E-02 Infectious Disease Human 1.4E-03-2.26E-02
Mouse 2.55E-10-1.18E-02 Mouse 2.8E-09-1.32E-02
Skeletal and Muscular Disorders Human 3.86E-04-2.26E-02 Genetic Disorder Human 4.04E-05-2.26E-02
Mouse 2.55E-10-1.53E-02 Mouse 9.79E-05-1.53E-02
Renal and Urological Disease Human 6.14E-04-2.26E-02 Hematological Disease Human 5.68E-05-2.17E-02
Mouse 1.68E-03-1.68E-03 Mouse 3.4E-04-1.06E-02
Gastrointestinal Disease Human 6.67E-04-2.26E-02 Dermatological Diseases and Conditions Human 1.45E-04-2.26E-02
Mouse 1.01E-03-1.54E-02 Mouse 4.82E-04-1.44E-02
Neurological Disease Human 1.21E-03-2.26E-02 Immunological Disease Human 1.7E-04-2.26E-02
Mouse 4.94E-04-1.53E-02 Mouse 2.19E-09-1.67E-02
Cell injury and repair
Cell Death Human 1.31E-03-2.26E-02 Organismal Survival Human 1.24E-02-1.24E-02
Mouse 8.56E-06-1.63E-02 Mouse 5.49E-03-1.56E-02
Cellular Compromise Human 2.13E-03-2.26E-02 Free Radical Scavenging Human 5.86E-04-9.62E-04
Mouse 4.41E-07-1.12E-02 Mouse 6.79E-04-1.5E-02
Cell Cycle Human 7.58E-03-2.26E-02 Cellular Growth and Proliferation Human 1.66E-06-2.26E-02
Mouse 3.73E-04-1.67E-02 Mouse 9.66E-08-1.44E-02
DNA Replication, Recombination, and Repair Human 1.51E-02-1.51E-02 Organismal Injury and Abnormalities Human 2.15E-03-2.15E-02
Mouse 4.36E-04-1.67E-02 Mouse 4.46E-05-1.64E-02
Development
Skeletal and Muscular System Development and Function Human 1.66E-06-1.51E-02 Hair and Skin Development and Function Human 1.34E-03-1.51E-02
Mouse 1.72E-06-1.67E-02 Mouse 3.5E-03-3.5E-03
Endocrine System Development and Function Human 1.68E-06-1.51E-02 Nervous System Development and Function Human 1.63E-03-1.51E-02
Mouse 1.99E-03-1.21E-02 Mouse 3.4E-04-1.39E-02
Tissue Development Human 1.15E-04-2.26E-02 Organ Development Human 7.58E-03-7.58E-03
Mouse 1.72E-06-1.45E-02 Mouse 1.83E-03-1.31E-02
Developmental Disorder Human 1.7E-04-2.26E-02 Organ Morphology Human 7.58E-03-7.58E-03
Mouse 9.79E-05-3.28E-03 Mouse 6.06E-05-1.39E-02
Tissue Morphology Human 3.38E-04-2.26E-02 Organismal Development Human 7.58E-03-1.51E-02
Mouse 2.92E-09-1.67E-02 Mouse 3.4E-04-1.31E-02
Renal and Urological System Development and Function Human 5.39E-04-1.51E-02 Visual System Development and Function Human 7.58E-03-2.26E-02
Mouse 1.01E-03-1.01E-03 Mouse 7.87E-03-1.31E-02
Cardiovascular System Development and Function Human 1.34E-03-2.26E-02 Organismal Functions Human 1.41E-02-1.41E-02
Mouse 5.92E-05-1.6E-02 Mouse 3.28E-03-4.03E-03
Embryonic Development Human 1.34E-03-1.51E-02 Connective Tissue Development and Function Human 1.51E-02-2.26E-02
Mouse 3.4E-04-1.99E-03 Mouse 1.72E-06-1.67E-02