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. 2014 Mar 24;9(3):e92751. doi: 10.1371/journal.pone.0092751

Figure 2. Sequences used in structurally modeling Leptin proteins throughout vertebrate evolution.

Figure 2

A) Amino acids that are conserved in all 16 models shown (red) on the known structure of human leptin, with the four helices identified. The four helix bundle is conserved in all species through hydrophobic amino acids. B) Z-score for each model as determined using the YASARA2 force field. Values between 0 and −2 are considered to be good models. C) Structural alignment of each of energy minimized models to the human structure showing the average carbon alpha RMDS in angstroms (Å).