Figure 3. Effects of maternal HFD during lactation on glucose intolerance and insulin resistance in the offspring.
GTT (A; male, C; female), ITT (B; male, D; female) at 24 weeks and HOMA-IR at 12 (E) and 24 (F) weeks of age. OCC: offspring from CD-fed dams suckled by CD-fed dams; OHC: offspring from HFD-fed dams suckled by CD-fed dams; OCH: offspring from CD-fed dams suckled by HFD-fed dams; OHH: offspring from HFD-fed dams suckled by HFD-fed dams. The results are shown as the mean ± SEM (n = 6 litter per group). *P<0.01, ** P<0.05 compared with the OCC mice and # P<0.01 compared with the OHC mice, $ P<0.01 between male and female offspring in OHH group.