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. 2014 Mar 24;9(3):e93151. doi: 10.1371/journal.pone.0093151

Figure 4. Celastrol downregulates interleukin-6 and NF-κB reporter activity in PC-3 cells.

Figure 4

(A) Luciferase activity of IL-6 reporter vector (pIL6-SX)-transfected PC-3 (black bars) and DU145 (white bars) cells treated with different concentrations of celastrol as indicated. (B) Luciferase activity of NFκB reporter vectors (black bars)- and MMTV reporter vector (white bars)-transfected PC-3 cells treated with different concentrations of celastrol as indicated. Data are presented as the mean percentage ± SE (n = 6) of the reporter activities induced by celastrol treatments in relation to the control solvent-treated group. (*p<0.05; **p<0.01).