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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Mol Microbiol. 2013 Oct 31;91(1):6–25. doi: 10.1111/mmi.12427

Figure 6. Structure of sensory domain of sensor histidine kinase (HK) chimera YF1 in light and dark conditions.

Figure 6

A. Complete structure of the functional YF1 (dark-adapted, 2.3 Å resolution), which is comprised of two N-terminal light-oxygen-voltage (LOV) photosensors linked by a coiled coil to the C-terminal effector modules of FixL, including the DHp and CA domains (Diensthuber et al., 2013).

B. Light and dark conformations of YF1 LOV sensory domain. The YF1 LOV photosensor domains in their dark-adapted state as determined by x-ray crystallography (left) are compared to a homology model of their light-adapted state (right) that is based on the structure of the Pseudomonas putida SB1 LOV protein (Circolone et al., 2012). Light absorption could induce quaternary structural rearrangements that culminate in a supertwist of the C-terminal coiled coil.