Table 2.
Mean, SD, and difference (95% CI) of WOMAC total, WOMAC pain, WOMAC stiffness, and WOMAC function scores and 6-minute walk distance at week 4 adjusted by week 0 in ibuprofen and Curcuma domestica groups
| Mean score at week 4 adjusted by week 0 ± SD | Ibuprofen (n=160) |
C. domestica extracts (n=171) |
Mean differencea (95% CI) |
P-value |
|---|---|---|---|---|
| WOMAC total score | 3.23±1.97 | 3.36±2.04 | −0.07 (−0.43, 0.29) | 0.010b |
| WOMAC pain subscale | 3.17±1.98 | 3.25±2.11 | −0.09 (−0.47, 0.29) | 0.018b |
| WOMAC stiffness subscale | 3.16±2.36 | 3.28±2.38 | −0.15 (−0.59, 0.29) | 0.060b |
| WOMAC function subscale | 3.26±2.05 | 3.41±2.09 | 0.06 (−0.43, 0.32) | 0.010b |
| 6-minute walk (meters) | 347.99±86.60 | 345.43±91.66 | 7.18 (−7.01, 21.38) | 0.320c |
Notes:
a
Estimated marginal means week 4 adjusted by week 0 of ibuprofen group minus C. domestica extracts group;
b
analysis of covariance and unpaired t-test for noninferiority test;
c
analysis of covariance for equality.
Abbreviations: CI, confidence interval; SD, standard deviation; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.