Table 3.

Adverse events (AEs) occurring during study compared between two groups

Adverse events	Ibuprofen (n=182)	Curcuma domestica extracts (n=185)	P-valuea
Number of patients with AE	65 (35.7%)	55 (29.7%)	0.222
Number of events
Abdominal pain/distension	33 (18.1%)	20 (10.8%)	0.046b
Dyspepsia	29 (15.9%)	21 (11.4%)	0.201
Nausea	15 (8.2%)	9 (4.9%)	0.191
Loose stool	16 (8.8%)	22 (11.9%)	0.330
Melena	2 (1.1%)	–	0.245
Pitting edema	13 (7.1%)	7 (3.8%)	0.156

Notes:

^aChi-square test, Fisher’s exact test;

^bstatistical significance.