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Model of autophagy regulation by BAT3. BAT3 regulates autophagy by modulating p300 localization and p300-dependent acetylation of p53 and ATG7. BAT3, allows the shuttling of p300 into the nucleus, where it targets p53 to stimulate autophagy. In contrast, when BAT3 is absent or exclusively cytosolic, p300 nuclear shuttling is inhibited, leading to its accumulation in the cytosol and to ATG7 hyperacetylation.
