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Silencing effects of cKK-E12 LPNs in nonhuman primates. Cynomolgus monkeys received a total dose of 0.3 mg/kg siTTR LPNs as 15-min i.v. infusions (5 mL/kg) through the cephalic vein. A liver biopsy was collected from each animal at 48 h postadministration. TTR mRNA levels relative to GAPDH mRNA levels were determined in liver samples. Control, Naive; TTR, transthyretin. Data points represent group mean ± SD (n = 3; *P < 0.05; t test, double-tailed).
