Fistularin 3, a brominated tyrosine-derived alkaloid and defensive metabolite that has the highest concentration in the tissues of the most abundant sponge, Aplysina cauliformis, based on the surveys conducted in this study. This compound and a complex mixture of related metabolites found in species of the genera Aplysina, Aiolochroia, and Verongula (24) constitute the most common chemical defense of Caribbean sponges.