Fig 2. Anesthetic-induced motor ataxia assessed with a fixed speed (8 rpm) rotarod did not differ between WT and α4 KO mice.
No differences between genotypes were observed in response to any of the drugs tested on this assay. a. Alphaxalone (50 mg/kg)- b. etomidate (20 mg/kg)- and c. propofol (25 mg/kg)-induced motor ataxia. Each point represents mean time on rotarod ± SEM. One KO mouse that was not impaired with etomidate treatment was eliminated from analysis. Similarly, for the alphaxalone assay, two WT mice that were unimpaired with alphaxalone treatment were eliminated from the analysis.