(A) Lcn2, S100a8, S100a9, (B) Duox2, Nos2, (C) Reg3g, and (D) Ido1 were detected by quantitative real time PCR in the cecum of WT mice and Il22−/− mice 72h after infection with WT S. Typhimurium. Infected WT n=6, infected Il22−/− n=6, mock n=4. Data are expressed as fold increase over mock-infected WT mice. Data represent the geometric mean ± standard error. A significant increase over mock control is indicated by * (P value ≤ 0.05), ** (P value ≤ 0.01) and *** (P value ≤ 0.001). (See also Fig. S5).