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. Author manuscript; available in PMC: 2015 Feb 20.
Published in final edited form as: Immunity. 2014 Feb 6;40(2):262–273. doi: 10.1016/j.immuni.2014.01.003

Figure 6. Expression of antimicrobial peptide genes in colonic crypts.

Figure 6

(A) Lcn2, S100a8 and S100a9 were detected by quantitative real time PCR in isolated colonic crypts of WT mice and Il22−/− mice 48h after infection with WT S. Typhimurium. Infected WT n=6, infected Il22−/− n=6, mock n=2. Data are expressed as fold increase over mock-infected WT mice. Data represent the geometric mean ± standard error (for some conditions error marks are not visible due to small error). A significant increase over mock control is indicated by ** (P value ≤ 0.01) and *** (P value ≤ 0.001). (B) Lcn-2, S100A8, S100A9, myeloperoxidase (MPO), and tubulin were detected 48h post infection by immunoblot in isolated crypts of WT and Il22−/− mice that were mock-infected or infected with S. Typhimurium.