Table 1.
Abbreviation | Assay |
---|---|
ACAA | Abdominal constrictions following intraperitoneal injection of acetic acid |
ACMS | Abdominal constrictions following intraperitoneal injection of magnesium sulfate |
AUT | Autotomy following transection of sciatic and saphenous nerves |
AUTSNN | Autotomy following spinal nerve neuroma induced by transection of lumbar nerves L4-L6 and saphenous nerve |
BV | Bee venom, intraplantar injection-induced hindpaw licking |
BVCON | Bee venom-induced thermal hypersensitivity assessed with Hargreaves’ test, contralateral hindpaw |
BVHT | Bee venom-induced thermal hypersensitivity assessed with Hargreaves’ test, ipsilateral hindpaw |
CAP | Capsaicin, intraplantar injection-induced hindpaw licking |
CAPTW | Capsaicin, tail injection-induced thermal hypersensitivity assessed with tail withdrawal from 47°C water |
CARHT | Carrageenan, intraplantar injection-induced thermal hypersensitivity assessed with Hargreaves’ test |
CHLITCH | Chloroquine, subcutaneous injection-induced maximum itch duration |
ComtB2i | Catechol-O-methyltransferase genotype as absence of B2 SINE in 3′ UTR |
CPLOCO | Cyclophosphamide cystitis, intraperitoneal injection-induced hypolocomotion |
DYNVF | Dynorphin, intrathecal injection-induced mechanical hypersensitivity assessed with von Frey test |
FEarly | Formalin, intraplantar injection-induced hindpaw licking, early/acute phase |
FLate | Formalin, intraplantar injection-induced hindpaw licking, late/tonic phase |
HISTITCH | Histamine, subcutaneous injection-induced itch duration |
HP | Hot-plate test, latency to paw withdrawal or jump response |
HT | Hargreaves’ plantar thermal nociception test, latency to paw withdrawal from light focused on hindpaw |
PACACET | Paclitaxel, intraperitoneal injection-induced cold hypersensitivity assessed with acetone test |
PACCOLD | Paclitaxel, intraperitoneal injection-induced cold hypersensitivity assessed with tail withdrawal from −15°C ethanol |
PACVF | Paclitaxel, intraperitoneal injection-induced mechanical hypersensitivity assessed with von Frey test |
PNIHT | Peripheral nerve injury#-induced thermal hypersensitivity assessed with Hargreaves’ test |
PNIVF | Peripheral nerve injury#-induced mechanical hypersensitivity assessed with von Frey test |
SNIACET | Spared nerve injury-induced cold hypersensitivity assessed with acetone test |
SNIVF | Spared nerve injury-induced mechanical hypersensitivity assessed with von Frey test |
TC | Tail-clip test, latency to bring nose to alligator clip applied to base of tail |
TF | Tail flick from radiant heat source, latency to flick tail |
TW−15 | Tail withdrawal from −15°C ethanol, latency to withdraw tail |
TW47.5 | Tail withdrawal from 47.5°C water, latency to withdraw tail |
TW49 | Tail withdrawal from 49°C water, latency to withdraw tail |
VF | von Frey monofilament test, 50% response threshold using up-down method |
ZYMACET | Zymosan, intraplantar injection-induced cold hypersensitivity assessed with acetone test |
ZYMHT | Zymosan, intraplantar injection-induced thermal hypersensitivity assessed with Hargreaves’ test |
Font color of abbreviations refers to the genetically distinct type of nociception or hypersensitivity identified previously [17]: (red) thermal nociception in otherwise naïve mice; (green) spontaneous responses to noxious chemical/inflammatory stimuli; (orange) thermal hypersensitivity; (blue) mechanical hypersensitivity; (purple) afferent input-dependent hypersensitivity. Brown font refers to mechanical sensitivity in naïve mice and mechanical nociception. Black font is used for assays newly included in the current analysis.
also referred to as the spinal nerve ligation (SNL) model.