Table S1.
Mutation subtypes detected by the OncoCarta Panel (v 1.0; Sequenom Inc., San Diego, CA, USA) MassARRAY
| Gene | Mutation subtypes |
|---|---|
| ABL1 | G250E; F317L; M351T; E355G; F359V; H396R; Q252H; Y253H; Y253F; E255K; E255V; D276G; F311L; T315I |
| AKT1 | rs11555435; rs11555431; rs11555432; rs12881616; rs11555433; rs11555436; rs34409589 |
| AKT2 | S302G; R371H |
| BRAF | G464R; F595L; G596R; L597S; L597R; L597Q; L597V; T599I; V600E; V600K; V600R; V600L; K601N; K601E; G464V |
| CDK | R24C; R24H |
| EGFR | R108K; S768I; V769_D770insASV; V769_D770insCV; D770_N771>AGG; V769_D770insASV; V769_D770insASV; D770_N771insG; N771_P772>SVDNR; P772_H773insV; H773>NPY; H773_V774insNPH; H773_V774insPH; H773_V774insH; V774_C775insHV; T263P; T790M; L858R; L861Q; A289V; G598V; E709K; E709H; E709A; E709G; E709V; G719S; G719C; G719A; M766_A767insAI; E746_T751del; E746_A750del; E746_A750del; E746_T751del; E746_A750del; E746_T751del; S752D; L747_E749del; L747_T750del; L747_S752del; L747_T751del; L747_S752del; P753S; L747_T751del; A750P; T751A; T751P; T751I; S752I/F; L747_Qins; E746_T751del; Iins; E746_A750del; T751A; E746_T751del; Vins; E746_A750del; Vins; L747_E749del; A750P; L747_T750del; Pins; L747_S752del; Qins; T751; S752_I759del |
| ERBB2 | L755P; G776S; G776LC; G776VC; A775_G776insYVMA; P780_Y781insGSP; P780_Y781insGSP; S779_P780insVGS |
| FGFR1 | S125L; P252T |
| FGFR3 | G370C; Y373C; A391E; K650Q; K650E; K650T; K650M |
| FLT3 | I836del; D835H; D835Y |
| HRAS | G12V; G12D; G13C; G13R; G13S; Q61H; Q61H; Q61L; Q61R; Q61P; Q61K |
| JAK2 | V617F |
| KIT | D52N; V559del; V559_V560del; V560del; P551_V555del; Y553_Q556del; Y570_L576del; E561K; L576P; P585P; D579del; Y503_F504insAY; K642E; D816V; D816H; D816Y; V825A; E839K; M552L; Y568D; F584S; W557R; W557R; W557G; V559D; V559A; V559G; V559I; V560D; V560G; K550_K558del; K558_V560del; K558_E562del |
| KRAS | G12V; G12A; G12D; G12C; G12S; G12R; G12F; G13V; G13D; A59T; Q61E; Q61K; Q61L; Q61R; Q61P; Q61H; Q61H |
| MET | R970C; T992I; Y1230C; Y1235D; M1250 |
| NRAS | G12V; G12A; G12D; G12C; G12R; G12S; G13V; G13A; G13D; G13C; G13R; G13S; A18T; Q61L; Q61R; Q61P; Q61H; Q61E; Q61K |
| PDGFRA | V561D; I843_S847>T; D842V; T674I; F808L; D846Y; N870S; D1071N; D842_H845del; I843_D846del; S566_E571>K |
| PIK3CA | R88Q; H1047Y; R38H; C901F; M1043I; M1043I; N345K; C420R; P539R; E542K; E545K; Q546K; H701P; H1047R; H1047L |
| RET | C634R; C634W; C634Y; E632_L633del; M918T; A664D |