Table S2.

Tests of between-subjects effects

Source	Type III sum of squares	df	Mean square	F	P-value
Corrected model	6.784a	20	0.339	1.777	0.033
	6.318	1	6.318	33.087	0.000
Sex	0.024	1	0.024	0.128	0.721
Mutation	1.250	1	1.250	6.544	0.012
Age	0.012	1	0.012	0.065	0.799
WHO	0.258	1	0.258	1.351	0.248
Clinical staging	0.003	1	0.003	0.018	0.893
Sex * mutation	3.536×10−5	1	3.536×10−5	0.000	0.989
Sex * age	0.284	1	0.284	1.486	0.226
Sex * WHO	0.031	1	0.031	0.165	0.686
Sex * clinical staging	0.053	1	0.053	0.276	0.600
Mutation * age	0.251	1	0.251	1.316	0.254
Mutation * WHO	0.012	1	0.012	0.065	0.800
Mutation * clinical staging	0.473	1	0.473	2.475	0.119
Age * WHO	0.414	1	0.414	2.168	0.144
Age * clinical staging	0.027	1	0.027	0.141	0.708
WHO * clinical staging	0.307	1	0.307	1.607	0.208
Sex * mutation * age	0.000	0	–	–	–
Sex * mutation * WHO	0.000	0	–	–	–
Sex * mutation * clinical staging	0.000	0	–	–	–
Sex * age * WHO	0.462	1	0.462	2.419	0.123
Sex * age * clinical staging	2.665×10−5	1	2.665×10−5	0.000	0.991
Sex * WHO * clinical staging	0.037	1	0.037	0.195	0.660
Mutation * age * WHO	0.000	0	–	–	–
Mutation * age * clinical staging	0.000	0	–	–	–
Mutation * WHO * clinical staging	0.000	0	–	–	–
Age * WHO * clinical staging	0.000	0	–	–	–
Sex * mutation * age * WHO	0.000	0	–	–	–
Sex * mutation * age *	0.000	0	–	–	–
Clinical staging
Sex * mutation * WHO *	0.000	0	–	–	–
Clinical staging
Sex * age * WHO *	0.000	0	–	–	–
Clinical staging
Mutation * age * WHO *	0.000	0	–	–	–
Clinical staging
Sex * mutation * age *	0.000	0	–	–	–
WHO * clinical staging
Error	19.476	102	0.191
Total	38.000	123
Corrected total	26.260	122

Note: Dependent variable: relapse/metastasis.

Abbreviation: WHO, World Health Organization.