Table 1. Pharmacokinetic values of (S)-YK-4-279 were obtained in SD rats following a single IV injection of racemic, (S)-YK-4-279 or (R)-YK-4-279.
| Treatment group (Target dose) | Gender | Observed | Cmax (¼M) | Terminal Elimination Half-Life (hr) | Clearance (mL/hr/kg) | AUClast (hr*¼M) | AUC∞ (hr*¼M) |
|---|---|---|---|---|---|---|---|
| Group 1: Racemic YK-4-279 (25 mg/kg) | Male (n=9) | 39.9 | 0.564 | 2560 | 26.5 | 26.7 | |
| Female (n=9) | 37.1 | 0.602 | 2640 | 25.6 | 25.9 | ||
| Group 2: (S)-YK-4-279 (25 mg/kg) | Male (n=9) | 85.5 | 0.694 | 1300 | 52.4 | 52.4 | |
| Female (n=9) | 86.6 | 0.476 | 1220 | 56.0 | 56.0 | ||
| Group 3: (R)-YK-4-279 (25 mg/kg) | Male (n=9) | BLOQ1 | BLOQ | BLOQ | BLOQ | BLOQ | |
| Female (n=9) | BLOQ | BLOQ | BLOQ | BLOQ | BLOQ |
1. BLOQ: below the limit of quantitation