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. 2013 Dec 7;5(2):363–374. doi: 10.18632/oncotarget.1620

Figure 3. EFEMP1 induces Notch signaling in glioblastoma cells.

Figure 3

A, schematic overview of EFEMP1 activation of EGFR [19] and Notch [22] signaling. MAGP-1/2, CCN3, YB-1, DLL, and Jagged are alternative Notch ligands [46–48, 50, 51]. B, mRNA expression of the Notch-induced genes HES1 and HEY1 in the TMZ-resistant glioblastoma cells as determined by qRT-PCR. C, cell viability analysis of Hs683-WT and Hs683-Rl glioblastoma cells four days after treatment with TMZ and DAPT (25 μM). D, HES1 expression after treatment with clinically available GSIs R04929097, BMS-708163, LY450139, and MK-0752 as determined by qRT-PCR. E, cell viability analysis of Hs683-WT and Hs683-R1 four days after treatment with TMZ and RO4929097 (50 μM). Shown are averages, error bars indicate SD. *p<0.05 t test.