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. 2014 Jan 11;5(2):438–450. doi: 10.18632/oncotarget.1686

Figure 3. Amplification of OTX2 in Retinoblastomas.

Figure 3

(A) Heat map and (B) Manhattan plot of inferred log2 ratio of copy number for germline (G) and diagnostic (D) DNA samples of 3 out of 94 samples that carry an amplification in OTX2 detected by SNP6.0 array analysis. (C) OTX2 amplification was validated by quantitative real-time PCR. All data was normalized to CTNNA3 with normal diploid copy number. The dashed line is the cutoff for amplification ≥ 10 copies relative to matched normal DNA for that sample.