Table 4. Validated mutations in WGS retinoblastoma data.

Sample	tierl1	tier2	tier3	Total	Indels	SVs	CNV-AMP	CNV-Mb-AMP	CNV-DEL	CNV-Mb-DEL	Total-CNV-Mb
SJRB011	4(2)	12	72	88	0	24	6	72.52	7	146.24	218.77
SJRB014	0	2	23	25	0	11	3	218.39	6	5.42	223.82
SJRB016	0	0	2	2	0	1	0	0	0	0	0
SJRB020	0	6	45	51	0	3	5	136.31	2	243.93	380.25
SJRB024	3(0)	8	73	84	1	28	38	903.47	0	0	903.47
SJRB031	32(15)	59	467	558	0	74	100	2840.21	13	0.49	2840.70
SJRB032	12(5)	17	171	200	0	17	46	2787.49	0	0	2787.49
SJRB035	0	1	22	23	0	0	0	0	0	0	0
SJRB039	7(2)	12	94	113	0	96	48	227.68	75	117.54	345.23
SJRB051	2(1)	5	50	57	0	52	5	250.60	31	11.19	261.79

¹Tier 1 mutations include all mutations in genes including silent mutations and mutations in the 5′ and 3′ UTRs. The number of nonsynonymous mutations that alter the coding sequence are shown in parentheses.