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. 2014 Feb 20;2(3):323–336. doi: 10.1016/j.stemcr.2014.01.006

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© 2014 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The Autonomous Activity of IANs Depends on Persistent Active Sodium Channels, but Not on LTCCs

(A–E) PSC neurons cultivated on MEAs were preincubated with G/A/N and treated with (A and C) the persistent sodium current blocker riluzole or (B, D, and E) the LTCC antagonist isradipine or LTCC agonist FPL64176.

(A) Concentration-dependent impact of riluzole on neuronal activity (n = 5).

(B) Impact of isradipine and FPL64176 on neuronal activity after 15 min and 60 min (n = 5 each).

(C) Representative SRPs (i) before and (ii) after the application of 10 μM riluzole.

(D and E) Representative SRPs before and after the application of (D) isradipine and (E) FPL64176. Data are mean values ± SD. See also Figure S5 for the impact of acetylcholine and glycine on the spontaneous neuronal activity of PSC neurons.

See also Table S1 and S2.