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. 2014 Feb 27;2(3):295–310. doi: 10.1016/j.stemcr.2014.01.009

Figure 7.

Figure 7

Attenuated Spontaneous Neurotransmitter Release in SCZD Neurons

(A and B) Fluorescence micrographs of representative control (A) and SCZD (B) neurons labeled with the PROX1-EGFP lentiviral vector. Scale bar, 15 μm.

(C–F) Electrophysiological properties of control and SCZD neurons; transient Na+ currents and sustained K+ currents in response to voltage step depolarizations in control (C) and SCZD (D) neurons (command voltage varied from −20 to +30 mV in 5 mV increments when cells were voltage-clamped at −70 mV); action potentials evoked by somatic current injections in control (E) and SCZD (F) neurons (cells current-clamped at −60 mV, injected currents from 10 to 20 pA).

(G) Representative traces of spontaneous postsynaptic currents in control and SCZD neurons.

(H) Quantification of the frequency and amplitude of postsynaptic currents in control and SCZD neurons. ∗p < 0.05, ∗∗p < 0.01; n = 40 control neurons, 42 SCZD neurons; two-tailed t test. Data are presented as mean ± SEM.