Model depicting modulation of gene expression, metabolism, and proliferative properties of breast cancer cells by ERα and ERβ, based on findings in this report. The three cell contexts are illustrated, ERα at top, ERα/ERβ in middle (as both homo and heterodimers), and ERβ at bottom. Sites are shown with both SRC3 and RIP140 (right), and RIP140 and other factors, but not SRC3 (left). Representative associations between binding site clusters and cellular regulations are illustrated. These include antiproliferative actions of ERβ through utilization of novel mechanisms, including modulation of transcription by ERα, changes in MAPK signaling, and alteration in adipogenesis in breast cancer cells.