Figure 1.

General outline of the study. A panel of six colon cancer cell lines was chosen, and profiled by sequencing selected cancer-related genes. The cells were then systematically perturbed with four kinase inhibitors and two ligands of growth receptors, and phosphorylation of key signaling proteins was measured using the Luminex platform. These data were used for parameterizing a mathematical model, which was then used to predict combinatorial treatments.