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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Proteomics. 2013 Apr;13(7):1065–1076. doi: 10.1002/pmic.201200482

Figure 2. Steiner-tree approach.

Figure 2

A: Initial protein-protein interaction network including input proteins (terminal nodes marked in red). B: Edge confidence score, based on functional similarity (GO biological process) of connected proteins (scale: 0 to 1). C: Determination of the Steiner nodes (in green) connecting all input proteins with a minimal overall sum of edge costs. Edge cost is defined as the inverse of interaction confidence. D: Ranking of Steiner node proteins according to summed confidence scores of edges directly connecting them to terminal nodes.