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. 2014 Feb 15;4(5):460–474. doi: 10.7150/thno.8077

Figure 3.

Figure 3

Figure 3

Optical imaging of metastatic animal model of MDA-MB-231 triple negative breast cancer cells stably expressing HSV1-sr39TK-NTR and treated with a combination of CB1954 and GCV. A. Upper panel shows the control nude mice treated with vehicle control imaged over time with D-Luciferin substrate and lower panel shows Fluc imaging of animal group treated with GCV alone. B. Upper panel shows the TK-NTR in MDA-MB-231 metastatic tumor in nude mice treated with CB1954 and GCV combination and imaged over time with D-Luciferin substrate. Lower panel shows the optical images of animal treated with CB1954 alone. Metastatic animal models were divided in to two groups (n=3 to 5) and treated with 2 doses of CB1954 + GCV combined and CB1954 alone at different time point. Imaging was done with cooled CCD camera (IVIS Spectrum) daily over a period of 9 days. Graph shows the Fluc signal level of animal group in different days treated with C, GCV and D, GCV + 1954, The animals treated with vehicle control and CB1954 alone increase in tumor size.