Skip to main content
. 2014 Feb 15;4(5):460–474. doi: 10.7150/thno.8077

Figure 4.

Figure 4

Figure 4

Figure 4

Therapeutic evaluation of GCV (40 mg/kg) + CB1954 (40 mg/kg) combination in MDA-MB-231 metastatic tumor stably expressing HSV1-sr39TK-NTR in mouse model by optical bioluminescence and µPET/CT imaging. A. Upper panel shows the optical images captured with control nude mice group and animals treated with GCV + CB1954, Lower panel shows the 18F-FHBG μPET/CT images acquired in vehicle treated animal group. B. PET, CT, and PET-CT fusion images in transverse position at the lung metastatic tumor plane of animal 2 and 3 of control group (C2 and C3), and animal 3 of treatment group (T3). C. Optical bioluminescence signal in control animal group measured over time. D. Optical bioluminescence signal measured in animal group treated with two doses of a combination of GCV and CB1954. E. µPET/CT imaging signal (%ID/g) measured in control and treatment group before and after two doses of combination therapy.