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. Author manuscript; available in PMC: 2014 Mar 25.
Published in final edited form as: Nat Med. 2013 May 5;19(6):695–703. doi: 10.1038/nm.3155

Figure 3.

Figure 3

Reduced BM recovery after cisplatin chemotherapy is due to SNS injury. (a) Representative immunofluorescence images of superior cervical ganglia showing apoptosis by TUNEL stain (red) in sympathetic neurons (Th, blue) of wild-type or Th-Cre:Trp53Δ/Δ mice 12h after cisplatin injection. Scale bar 25 μm (b) Representative immunofluorescence image of Th+ fibers in the BM of a Th-Cre:Trp53Δ/Δ mouse after cisplatin. Scale bar, 50 μm. (c) Quantification of Th+ fibers in the BM of cisplatin-treated control (WT) or Th-Cre:Trp53Δ/Δ (KO) mice, 4 weeks after the last cisplatin injection. (n = 3) (d) Overall survival of wild-type (WT; n = 18) or Th-Cre:Trp53Δ/Δ (n = 10) mice after cisplatin treatment and transplantation (n = 6–12). (e) BMNC, CFU-C and LSKF cells per femur in the BM of WT or Th-Cre:Trp53Δ/Δ (KO) littermates treated with saline or cisplatin 4 weeks after transplantation (n = 4–10).