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. 2014 Mar 13;63(4):1366–1380. doi: 10.2337/db13-1412

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© 2014 by the American Diabetes Association.

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Decreased expression of Rap1b in renal tissues of patients with DN. A: PASM and PAS staining show tubular atrophy and interstitial fibrosis in renal biopsies in patients with DN (Aa–Ad) (magnification ×100). IHC studies revealed decreased expression of Rap1b in DN patients (Af vs. Ae). Using EM, notable deformations were seen in the tubular mitochondria of renal tissue of DN patients compared with N-DN (Ah vs. Ag) (magnification ×10,000). B: Averaged relative intensity following staining of anti-Rap1b antibody of kidney biopsies of DN versus N-DN patients. *P < 0.01. C and D: Serum creatinine (Scr) and blood glucose levels in DN and N-DN patients. *P < 0.01. E: Relative percentage of renal tubular cells with elongated mitochondria in DN versus N-DN patients. *P < 0.01 versus N-DN. F and G: Scatter plots show relationship between Rap1b expression and tubular interstitial damage and urinary β-NAG levels. Values are means ± SE.